![]() ![]() ![]() Current conventional treatment regimen including hydration, diuretics and nonsteroidal anti-inflammatory drugs can only partially reduce polyuria. Sildenafil for the Treatment of Congenital Nephrogenic Diabetes Insipidus.Ĭongenital nephrogenic diabetes insipidus (NDI) is characterized by massive polyuria and polydipsia due to defects in the vasopressin-sensitive signaling system expression of the acuaporin-2 (AQP2) water channel of the kidney collecting duct principal cells. Thus, sil-denafil treatment of macular degeneration offers significant potential for vision retention and recovery. Notably, maintenance or improvement in the photoreceptor layer may be the most significant result of sildenafil and is consistent with PDE6 inhibition. Thickened Bruch's membrane reduces the beneficial effect of perfusion increase, but all eyes appear to benefit from PDE6. Our research supports sildenafil as a safe treatment for age-related and vitelliform macular degenerations. A participant with Best vitelliform macular dystrophy had a significant improvement in vision as well as in photoreceptor and ellipsoid layers. Vitelliform-type soft drusen were not substantially changed. Sildenafil was prescribed to treat participants with macular degenerations or macular dystrophies measured by spectral-domain optical coherence tomography, color fundus photography, enhanced depth imaging, and best- corrected visual acuity. To evaluate PDE5/6 inhibition with sildenafil to reduce choroidal ischemia and treat age-related macular degeneration. Treatment of Macular Degeneration with Sildenafil: Results of a Two-Year Trial.Ĭoleman, D Jackson Lee, Winston Chang, Stanley Silverman, Ronald H Lloyd, Harriet O Daly, Suzanne Tsang, Stephen H ![]()
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